2321 Experimental uveitogenic antigens and their role in clinical uveitis

PlXDOSO: TO assess the possible role Of experimental uveitogenic antigens (S-Ag, IRPB and recoverin) in human uveitis. Methods : Patients suffering from non-infectious bilateral UVeitiS and from the Ocular type of Behcet's disease were included in this study. Patients’ lymphocytes were tested for their possible in vitro anamnestic immune ~~SpClllS~ (specific blast transformation) to S-Ag, IRBP ;;i recoverin. The tests were carried out recorded in a masked manner. Results: Lymphocytes obtained from patients showed an unexpectedly low incidence of IXSpOtlSe towards SAg and IRBP. This .low incidence of specific response was only slightly higher than that observed for the group of healthy volunteers included as controls. To recoverin, there was no specific response of either the patients’ lymphocytes or those of healthy controls. conclusions: These data may be interpreted to indicate: antigens (52; The experimental uveitogenic IRBP and recoverin) may role in the uveitis observed in humans. Play a However, the sensitized lymphocytes “home” to the eye and therefore are not detected in the circulation. b) The experimental uveitogenic antigens known to date do not play a major role in the uveitis as observed in humans.